Neuronal+Degeneration+and+Regeneration

=**Neuronal Degeneration and Regeneration**=


 * 1. List some factors that can directly or indirectly cause degeneration and death of neurons.**


 * 2. Describe morphological changes in cell body and central and distal portions of its axon after its axon has been severed or crushed.**


 * 3. Define apoptosis and describe its physical characteristics and gene regulatory mechanism.**


 * 4. Describe steps in neuronal regeneration and molecules that are important for neuronal survival, axon outgrowth, target innervation, and synapse formation.**


 * 5. Recount what role glia play in promoting regeneration of peripheral axons and limiting central axon regeneration. Describe experimental results that demonstrate how peripheral axons grafted into the CNS may bridge areas of damage.**


 * 6. Describe neurosurgical interventions for peripheral nerve repair.**


 * 7. Describe what potential therapies may arise from findings about the existence of neuronal stem cells in the adult brain and how transplantation of genetically engineered cells may compensate for neurons lost due to degenerative diseases.**